Drug interactions
Clorazepate + Protriptyline
Severity: Moderate
Clorazepate and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and psychomotor impairment, and protriptyline adds anticholinergic effects. Together they may increase sedation, confusion and fall risk, especially in older adults.
What this interaction means in plain words
Clorazepate and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and tricyclic antidepressant antihistaminic and anticholinergic effects.
What to do
Monitor for oversedation and cognitive impairment, and use the lowest effective doses. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Protriptyline?
MediHelp rates the interaction as moderate. Clorazepate and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness and psychomotor impairment, and protriptyline adds anticholinergic effects. Together they may increase sedation, confusion and fall risk, especially in older adults.
How serious is the interaction between Clorazepate and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and cognitive impairment, and use the lowest effective doses. Counsel against driving and alcohol.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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