Drug interactions
Clorazepate + Quazepam
Severity: Moderate
Clorazepate and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two benzodiazepines together provides additive sedation, psychomotor impairment and respiratory depression without a clear therapeutic benefit. The risk of falls and next-day impairment is increased.
What this interaction means in plain words
Clorazepate and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Avoid concurrent use of two benzodiazepines where possible, consolidating to a single agent. If both are required, use the lowest doses and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Quazepam?
MediHelp rates the interaction as moderate. Clorazepate and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking two benzodiazepines together provides additive sedation, psychomotor impairment and respiratory depression without a clear therapeutic benefit. The risk of falls and next-day impairment is increased.
How serious is the interaction between Clorazepate and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines where possible, consolidating to a single agent. If both are required, use the lowest doses and monitor for sedation and respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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