Drug interactions
Clorazepate + Remimazolam
Severity: Major
Clorazepate and Remimazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a short-acting benzodiazepine, and combined use with clorazepate adds to sedation and respiratory depression. Profound sedation or hypoventilation can occur during procedures.
What this interaction means in plain words
Clorazepate and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clorazepate belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor-mediated central nervous system depression.
What to do
Titrate remimazolam carefully, using lower doses if needed, with continuous monitoring of oxygen saturation and vital signs through recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Remimazolam
Frequently asked questions
Can I take Clorazepate with Remimazolam?
MediHelp rates the interaction as major. Clorazepate and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam is a short-acting benzodiazepine, and combined use with clorazepate adds to sedation and respiratory depression. Profound sedation or hypoventilation can occur during procedures.
How serious is the interaction between Clorazepate and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, using lower doses if needed, with continuous monitoring of oxygen saturation and vital signs through recovery.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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