Drug interactions
Clorazepate + Triazolam
Severity: Moderate
Clorazepate and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two benzodiazepines produces additive central nervous system depression, with more sedation, impaired psychomotor performance and a higher risk of respiratory depression. Falls and next-day impairment are particularly concerning in older adults.
What this interaction means in plain words
Clorazepate and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both drugs enhance GABA-A receptor mediated inhibition, producing additive CNS depression.
What to do
Avoid routine duplication of benzodiazepines; if both are unavoidable, use the lowest effective doses and monitor for oversedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Triazolam?
MediHelp rates the interaction as moderate. Clorazepate and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two benzodiazepines produces additive central nervous system depression, with more sedation, impaired psychomotor performance and a higher risk of respiratory depression. Falls and next-day impairment are particularly concerning in older adults.
How serious is the interaction between Clorazepate and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of benzodiazepines; if both are unavoidable, use the lowest effective doses and monitor for oversedation and respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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