Drug interactions
Clorazepate + Triprolidine
Severity: Moderate
Clorazepate and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clorazepate is a benzodiazepine, and combining it with sedating triprolidine produces additive drowsiness and psychomotor impairment. This is most relevant in older adults and in those who drive or work with machinery.
What this interaction means in plain words
Clorazepate and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-receptor antagonism and enhanced GABA-A activity.
What to do
Advise patients to avoid driving and alcohol, and use the lowest effective doses. Choose a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Triprolidine?
MediHelp rates the interaction as moderate. Clorazepate and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clorazepate is a benzodiazepine, and combining it with sedating triprolidine produces additive drowsiness and psychomotor impairment. This is most relevant in older adults and in those who drive or work with machinery.
How serious is the interaction between Clorazepate and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol, and use the lowest effective doses. Choose a non-sedating antihistamine where possible.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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