Drug interactions
Clorazepate + Valerian
Severity: Moderate
Clorazepate and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has mild sedative properties and may add to the CNS depression produced by benzodiazepines. This can increase drowsiness, impaired concentration and psychomotor slowing, although clinically severe events are uncommon.
What this interaction means in plain words
Clorazepate and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, as valerian constituents are thought to modulate GABA-A receptor activity.
What to do
Advise patients to avoid valerian products while taking clorazepate, or counsel on driving and machinery risk. Reduce or stop valerian if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Valerian?
MediHelp rates the interaction as moderate. Clorazepate and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has mild sedative properties and may add to the CNS depression produced by benzodiazepines. This can increase drowsiness, impaired concentration and psychomotor slowing, although clinically severe events are uncommon.
How serious is the interaction between Clorazepate and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid valerian products while taking clorazepate, or counsel on driving and machinery risk. Reduce or stop valerian if excess sedation occurs.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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