Drug interactions
Clorazepate + Zotepine
Severity: Moderate
Clorazepate and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine is a sedating atypical antipsychotic; with a benzodiazepine it can produce more drowsiness, hypotension and impaired coordination. Zotepine also lowers seizure threshold, which may oppose the anticonvulsant effect of clorazepate.
What this interaction means in plain words
Clorazepate and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic receptor blockade.
What to do
Use the lowest effective doses and monitor sedation and blood pressure; be cautious in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Zotepine?
MediHelp rates the interaction as moderate. Clorazepate and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine is a sedating atypical antipsychotic; with a benzodiazepine it can produce more drowsiness, hypotension and impaired coordination. Zotepine also lowers seizure threshold, which may oppose the anticonvulsant effect of clorazepate.
How serious is the interaction between Clorazepate and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure; be cautious in patients with epilepsy.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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