Drug interactions
Clotrimazole + Gliclazide
Severity: Minor
Clotrimazole and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic azole antifungals inhibit CYP2C9 and can raise sulfonylurea levels, but topical or lozenge clotrimazole has little systemic absorption. Clinically meaningful interaction is unlikely with local use.
What this interaction means in plain words
Clotrimazole and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clotrimazole belongs to Anti Fungals; Gliclazide belongs to Endocrine.
Why it happens
Azole inhibition of CYP2C9 could reduce gliclazide clearance, but systemic exposure to clotrimazole is minimal.
What to do
No action is needed for topical or vaginal use; monitor glucose if prolonged oral lozenges are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Frequently asked questions
Can I take Clotrimazole with Gliclazide?
MediHelp rates the interaction as minor. Clotrimazole and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic azole antifungals inhibit CYP2C9 and can raise sulfonylurea levels, but topical or lozenge clotrimazole has little systemic absorption. Clinically meaningful interaction is unlikely with local use.
How serious is the interaction between Clotrimazole and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for topical or vaginal use; monitor glucose if prolonged oral lozenges are used.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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