Drug interactions
Clotrimazole + Glipizide-metformin
Severity: Minor
Clotrimazole and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical or vaginal clotrimazole is minimally absorbed and unlikely to affect glipizide exposure. Systemic azole effects on sulfonylureas do not meaningfully apply to these preparations.
What this interaction means in plain words
Clotrimazole and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clotrimazole belongs to Anti Fungals; Glipizide-metformin belongs to Endocrine.
Why it happens
Systemic azoles inhibit CYP2C9 which metabolises glipizide, but clotrimazole's systemic exposure is negligible.
What to do
No action is needed for topical use; with lozenges or prolonged use, be aware of hypoglycemia and check glucose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clotrimazole and Glipizide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Frequently asked questions
Can I take Clotrimazole with Glipizide-metformin?
MediHelp rates the interaction as minor. Clotrimazole and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical or vaginal clotrimazole is minimally absorbed and unlikely to affect glipizide exposure. Systemic azole effects on sulfonylureas do not meaningfully apply to these preparations.
How serious is the interaction between Clotrimazole and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for topical use; with lozenges or prolonged use, be aware of hypoglycemia and check glucose if symptoms occur.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
