Drug interactions
Clotrimazole + Glyburide-metformin
Severity: Minor
Clotrimazole and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic azole antifungals can raise sulfonylurea concentrations and cause hypoglycemia. Clotrimazole is mostly used topically or as lozenges, so systemic exposure is generally low and the interaction is of limited relevance.
What this interaction means in plain words
Clotrimazole and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clotrimazole belongs to Anti Fungals; Glyburide-metformin belongs to Endocrine.
Why it happens
Azoles can inhibit CYP2C9 and CYP3A4, which reduces glyburide metabolism, though systemic clotrimazole exposure is small.
What to do
No routine change is required for topical use. With prolonged lozenge use, ask patients to report symptoms of hypoglycemia and check blood glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Frequently asked questions
Can I take Clotrimazole with Glyburide-metformin?
MediHelp rates the interaction as minor. Clotrimazole and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic azole antifungals can raise sulfonylurea concentrations and cause hypoglycemia. Clotrimazole is mostly used topically or as lozenges, so systemic exposure is generally low and the interaction is of limited relevance.
How serious is the interaction between Clotrimazole and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required for topical use. With prolonged lozenge use, ask patients to report symptoms of hypoglycemia and check blood glucose.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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