Drug interactions
Clotrimazole + Tadalafil
Severity: Minor
Clotrimazole and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clotrimazole taken systemically (for example as lozenges or troches) may modestly raise tadalafil exposure through CYP3A4 inhibition. Higher tadalafil levels can increase headache, flushing, dyspepsia and hypotension. Topical use is unlikely to matter.
What this interaction means in plain words
Clotrimazole and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clotrimazole belongs to Anti Fungals; Tadalafil belongs to Genitourinary.
Why it happens
Clotrimazole weakly to moderately inhibits CYP3A4, reducing tadalafil clearance.
What to do
No routine dose change is needed for lozenge or topical clotrimazole; counsel the patient about vasodilatory adverse effects. Consider a lower tadalafil dose if prolonged oral exposure occurs and adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Frequently asked questions
Can I take Clotrimazole with Tadalafil?
MediHelp rates the interaction as minor. Clotrimazole and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clotrimazole taken systemically (for example as lozenges or troches) may modestly raise tadalafil exposure through CYP3A4 inhibition. Higher tadalafil levels can increase headache, flushing, dyspepsia and hypotension. Topical use is unlikely to matter.
How serious is the interaction between Clotrimazole and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for lozenge or topical clotrimazole; counsel the patient about vasodilatory adverse effects. Consider a lower tadalafil dose if prolonged oral exposure occurs and adverse effects emerge.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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