Drug interactions
Clotrimazole + Trabectedin
Severity: Moderate
Clotrimazole and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is cleared mainly by CYP3A4, and strong inhibitors of this enzyme can substantially raise its exposure and the risk of hepatotoxicity and myelosuppression. Clotrimazole is a weak inhibitor with limited systemic absorption in topical or lozenge forms, so the effect is likely small.
What this interaction means in plain words
Clotrimazole and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Trabectedin belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by clotrimazole may reduce trabectedin metabolism.
What to do
Monitor liver enzymes, bilirubin and blood counts closely if clotrimazole is given systemically or long term. Consider an alternative antifungal that does not inhibit CYP3A4 if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Other interactions of Trabectedin
Frequently asked questions
Can I take Clotrimazole with Trabectedin?
MediHelp rates the interaction as moderate. Clotrimazole and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trabectedin is cleared mainly by CYP3A4, and strong inhibitors of this enzyme can substantially raise its exposure and the risk of hepatotoxicity and myelosuppression. Clotrimazole is a weak inhibitor with limited systemic absorption in topical or lozenge forms, so the effect is likely small.
How serious is the interaction between Clotrimazole and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, bilirubin and blood counts closely if clotrimazole is given systemically or long term. Consider an alternative antifungal that does not inhibit CYP3A4 if possible.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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