Drug interactions
Clozapine + Dapagliflozin-metformin
Severity: Moderate
Clozapine and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes. This can substantially reduce the effectiveness of dapagliflozin-metformin and may precipitate ketoacidosis in severe cases.
What this interaction means in plain words
Clozapine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through clozapine-induced insulin resistance and impaired insulin secretion.
What to do
Monitor glucose and HbA1c regularly and adjust antidiabetic therapy. Be alert for ketoacidosis and metabolic deterioration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Clozapine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes. This can substantially reduce the effectiveness of dapagliflozin-metformin and may precipitate ketoacidosis in severe cases.
How serious is the interaction between Clozapine and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly and adjust antidiabetic therapy. Be alert for ketoacidosis and metabolic deterioration.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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