Drug interactions
Clozapine + Dutasteride-tamsulosin
Severity: Moderate
Clozapine and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has marked alpha-1 blocking activity and can cause orthostatic hypotension and syncope, which may be worsened by tamsulosin. Any pharmacokinetic effect through CYP2D6 is minor, and the pharmacodynamic additive effect is the main concern.
What this interaction means in plain words
Clozapine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade, with possible minor CYP2D6 inhibition.
What to do
Monitor blood pressure and orthostatic symptoms, particularly during clozapine titration. Counsel on slow position changes and adjust doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Clozapine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has marked alpha-1 blocking activity and can cause orthostatic hypotension and syncope, which may be worsened by tamsulosin. Any pharmacokinetic effect through CYP2D6 is minor, and the pharmacodynamic additive effect is the main concern.
How serious is the interaction between Clozapine and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly during clozapine titration. Counsel on slow position changes and adjust doses if hypotension occurs.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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