Drug interactions
Clozapine + Fluticasone-vilanterol
Severity: Moderate
Clozapine and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can prolong the QTc interval and cause tachycardia and myocarditis, and vilanterol may add cardiac stimulation and hypokalemia. The combination may increase arrhythmia risk.
What this interaction means in plain words
Clozapine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and sympathetic cardiac stimulation.
What to do
Monitor heart rate, ECG and electrolytes, especially in patients with cardiac disease. Report palpitations, chest pain or syncope promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Clozapine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can prolong the QTc interval and cause tachycardia and myocarditis, and vilanterol may add cardiac stimulation and hypokalemia. The combination may increase arrhythmia risk.
How serious is the interaction between Clozapine and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and electrolytes, especially in patients with cardiac disease. Report palpitations, chest pain or syncope promptly.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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