Drug interactions
Clozapine + Histrelin
Severity: Moderate
Clozapine and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can cause androgen deprivation which is associated with QT prolongation. Clozapine may also affect the QT interval, so combined use may increase arrhythmia risk.
What this interaction means in plain words
Clozapine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation, with androgen deprivation from GnRH agonism affecting cardiac repolarization.
What to do
Check baseline ECG and electrolytes and monitor QTc periodically. Correct electrolyte disturbances and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Clozapine with Histrelin?
MediHelp rates the interaction as moderate. Clozapine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can cause androgen deprivation which is associated with QT prolongation. Clozapine may also affect the QT interval, so combined use may increase arrhythmia risk.
How serious is the interaction between Clozapine and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor QTc periodically. Correct electrolyte disturbances and review other QT-prolonging drugs.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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