Drug interactions
Clozapine + Ipratropium-salbutamol
Severity: Minor
Clozapine and Ipratropium-salbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has strong anticholinergic activity that may add to ipratropium's effects, although systemic absorption of inhaled ipratropium is low. Combined use may contribute to constipation, urinary retention and tachycardia. Salbutamol may also add to clozapine's tachycardia.
What this interaction means in plain words
Clozapine and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive anticholinergic effects and additive sympathomimetic tachycardia.
What to do
No routine change is needed at standard doses. Monitor for constipation, urinary retention and tachycardia in patients on clozapine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium-salbutamol
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Ipratropium-salbutamol?
MediHelp rates the interaction as minor. Clozapine and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clozapine has strong anticholinergic activity that may add to ipratropium's effects, although systemic absorption of inhaled ipratropium is low. Combined use may contribute to constipation, urinary retention and tachycardia. Salbutamol may also add to clozapine's tachycardia.
How serious is the interaction between Clozapine and Ipratropium-salbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed at standard doses. Monitor for constipation, urinary retention and tachycardia in patients on clozapine.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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