Drug interactions
Clozapine + Lemborexant
Severity: Moderate
Clozapine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant and clozapine are both sedating, and combining them may increase drowsiness and next-day psychomotor impairment. This raises the risk of falls and accidents.
What this interaction means in plain words
Clozapine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression through orexin receptor antagonism and clozapine sedative properties.
What to do
Start with the lowest lemborexant dose and monitor for excessive sedation. Counsel patients about driving and activities requiring alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Clozapine with Lemborexant?
MediHelp rates the interaction as moderate. Clozapine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant and clozapine are both sedating, and combining them may increase drowsiness and next-day psychomotor impairment. This raises the risk of falls and accidents.
How serious is the interaction between Clozapine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest lemborexant dose and monitor for excessive sedation. Counsel patients about driving and activities requiring alertness.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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