Drug interactions
Clozapine + Leniolisib
Severity: Moderate
Clozapine and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak inhibitor of CYP1A2 and may raise clozapine concentrations. Clozapine has a narrow therapeutic index, so higher levels may cause sedation, seizures, hypotension, or cardiac effects.
What this interaction means in plain words
Clozapine and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2-mediated clozapine metabolism by leniolisib.
What to do
Monitor for clozapine adverse effects and consider checking clozapine plasma levels after starting or stopping leniolisib. Reduce the clozapine dose if levels or toxicity increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Clozapine with Leniolisib?
MediHelp rates the interaction as moderate. Clozapine and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is a weak inhibitor of CYP1A2 and may raise clozapine concentrations. Clozapine has a narrow therapeutic index, so higher levels may cause sedation, seizures, hypotension, or cardiac effects.
How serious is the interaction between Clozapine and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine adverse effects and consider checking clozapine plasma levels after starting or stopping leniolisib. Reduce the clozapine dose if levels or toxicity increase.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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