Drug interactions
Clozapine + Levetiracetam
Severity: Minor
Clozapine and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so the combination may increase sedation and impair alertness. Levetiracetam has also been linked to behavioral and psychiatric effects that may complicate psychiatric treatment.
What this interaction means in plain words
Clozapine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients about drowsiness and driving, and review the dose if excessive sedation occurs. Monitor mental state when levetiracetam is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Clozapine with Levetiracetam?
MediHelp rates the interaction as minor. Clozapine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence and dizziness, so the combination may increase sedation and impair alertness. Levetiracetam has also been linked to behavioral and psychiatric effects that may complicate psychiatric treatment.
How serious is the interaction between Clozapine and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving, and review the dose if excessive sedation occurs. Monitor mental state when levetiracetam is added.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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