Drug interactions
Clozapine + Levofloxacin
Severity: Moderate
Clozapine and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin and clozapine each have the potential to lengthen the QTc interval, so combined use may increase the chance of ventricular arrhythmia. Clozapine also carries risks of myocarditis and cardiomyopathy, which add to the cardiac vulnerability.
What this interaction means in plain words
Clozapine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization through potassium channel blockade.
What to do
Obtain a baseline ECG and check electrolytes, and repeat the ECG if symptoms such as palpitations or syncope occur. Choose a different antibiotic if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Levofloxacin?
MediHelp rates the interaction as moderate. Clozapine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin and clozapine each have the potential to lengthen the QTc interval, so combined use may increase the chance of ventricular arrhythmia. Clozapine also carries risks of myocarditis and cardiomyopathy, which add to the cardiac vulnerability.
How serious is the interaction between Clozapine and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check electrolytes, and repeat the ECG if symptoms such as palpitations or syncope occur. Choose a different antibiotic if the patient has other QT risk factors.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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