Drug interactions
Clozapine + Linagliptin-metformin
Severity: Moderate
Clozapine and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes, which can overwhelm the effect of metformin and linagliptin. Severe hyperglycemia and ketoacidosis have been reported with clozapine.
What this interaction means in plain words
Clozapine and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance, weight gain and impaired beta-cell function.
What to do
Monitor fasting glucose, HbA1c and weight regularly and intensify antidiabetic therapy as needed. Metformin is also used to mitigate clozapine-related weight gain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Linagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linagliptin-metformin
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Clozapine and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes, which can overwhelm the effect of metformin and linagliptin. Severe hyperglycemia and ketoacidosis have been reported with clozapine.
How serious is the interaction between Clozapine and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose, HbA1c and weight regularly and intensify antidiabetic therapy as needed. Metformin is also used to mitigate clozapine-related weight gain.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
