Drug interactions
Clozapine + Memantine-donepezil
Severity: Moderate
Clozapine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine and donepezil can both prolong the QT interval, raising the risk of arrhythmia. Clozapine is also strongly anticholinergic, which may counteract donepezil and worsen cognition, and donepezil may add to bradycardia risk.
What this interaction means in plain words
Clozapine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, plus pharmacodynamic opposition of cholinergic and anticholinergic effects.
What to do
Obtain a baseline ECG and monitor the QTc and electrolytes. Reassess cognitive benefit and consider the lowest effective clozapine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Clozapine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine and donepezil can both prolong the QT interval, raising the risk of arrhythmia. Clozapine is also strongly anticholinergic, which may counteract donepezil and worsen cognition, and donepezil may add to bradycardia risk.
How serious is the interaction between Clozapine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc and electrolytes. Reassess cognitive benefit and consider the lowest effective clozapine dose.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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