Drug interactions
Clozapine + Metaxalone
Severity: Moderate
Clozapine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is highly sedating and can cause orthostatic hypotension and, rarely, respiratory depression. Adding metaxalone may increase drowsiness and dizziness.
What this interaction means in plain words
Clozapine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and orthostatic hypotension, particularly when starting metaxalone. Reduce the dose or choose an alternative if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Metaxalone?
MediHelp rates the interaction as moderate. Clozapine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is highly sedating and can cause orthostatic hypotension and, rarely, respiratory depression. Adding metaxalone may increase drowsiness and dizziness.
How serious is the interaction between Clozapine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension, particularly when starting metaxalone. Reduce the dose or choose an alternative if sedation becomes problematic.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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