Drug interactions
Clozapine + Methocarbamol
Severity: Moderate
Clozapine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly sedating and can also cause orthostatic hypotension and respiratory depression in some situations. Adding methocarbamol may increase drowsiness, dizziness and the risk of falls.
What this interaction means in plain words
Clozapine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from an antipsychotic with strong antihistaminic and anti-adrenergic activity and a centrally acting muscle relaxant.
What to do
Monitor for oversedation, orthostatic hypotension and falls, especially during initiation or titration. Reduce the dose of one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Methocarbamol?
MediHelp rates the interaction as moderate. Clozapine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly sedating and can also cause orthostatic hypotension and respiratory depression in some situations. Adding methocarbamol may increase drowsiness, dizziness and the risk of falls.
How serious is the interaction between Clozapine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, orthostatic hypotension and falls, especially during initiation or titration. Reduce the dose of one agent if sedation is excessive.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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