Drug interactions
Clozapine + Methohexital
Severity: Major
Clozapine and Methohexital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic that causes deep CNS depression. With clozapine this may cause excess sedation, hypotension and respiratory depression, so airway and circulation need attention.
What this interaction means in plain words
Clozapine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression and additive hypotension.
What to do
Inform the anesthesia team of clozapine use and titrate methohexital carefully. Monitor airway, blood pressure and oxygenation continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Clozapine with Methohexital?
MediHelp rates the interaction as major. Clozapine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic that causes deep CNS depression. With clozapine this may cause excess sedation, hypotension and respiratory depression, so airway and circulation need attention.
How serious is the interaction between Clozapine and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of clozapine use and titrate methohexital carefully. Monitor airway, blood pressure and oxygenation continuously.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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