Drug interactions
Clozapine + Naratriptan
Severity: Moderate
Clozapine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect serotonergic transmission, so combined use carries a theoretical risk of serotonin syndrome. Reports of serotonin syndrome with triptans and antipsychotics are rare.
What this interaction means in plain words
Clozapine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity (5-HT1B/1D agonism with 5-HT2A antagonism and other receptor effects).
What to do
Counsel patients to report agitation, tremor, fever, sweating or muscle rigidity. Stop the triptan and evaluate urgently if such symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Clozapine with Naratriptan?
MediHelp rates the interaction as moderate. Clozapine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs affect serotonergic transmission, so combined use carries a theoretical risk of serotonin syndrome. Reports of serotonin syndrome with triptans and antipsychotics are rare.
How serious is the interaction between Clozapine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, fever, sweating or muscle rigidity. Stop the triptan and evaluate urgently if such symptoms appear.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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