Drug interactions
Clozapine + Oxymorphone
Severity: Moderate
Clozapine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly sedating and can cause respiratory and circulatory depression, particularly at initiation. Together with an opioid, sedation, hypotension and respiratory depression may be additive.
What this interaction means in plain words
Clozapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects from opioid receptor agonism and the antihistaminic, anti-adrenergic and antimuscarinic properties of clozapine.
What to do
Start the opioid at a low dose and titrate slowly, monitoring sedation, blood pressure and respiratory rate. Take extra care during clozapine initiation or dose escalation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Oxymorphone?
MediHelp rates the interaction as moderate. Clozapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly sedating and can cause respiratory and circulatory depression, particularly at initiation. Together with an opioid, sedation, hypotension and respiratory depression may be additive.
How serious is the interaction between Clozapine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the opioid at a low dose and titrate slowly, monitoring sedation, blood pressure and respiratory rate. Take extra care during clozapine initiation or dose escalation.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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