Drug interactions
Clozapine + Procarbazine
Severity: Moderate
Clozapine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitory activity and may add to serotonergic effects of clozapine, with a theoretical risk of serotonin toxicity. Both drugs can also cause CNS depression, and clozapine carries a risk of neuroleptic malignant syndrome. Procarbazine is also myelosuppressive, adding to clozapine's risk of neutropenia.
What this interaction means in plain words
Clozapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive serotonergic and CNS effects from MAO inhibition by procarbazine, plus additive myelosuppression.
What to do
Monitor for agitation, hyperthermia, rigidity and autonomic instability, and follow blood counts closely. Consider an alternative antipsychotic if marrow suppression develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Clozapine with Procarbazine?
MediHelp rates the interaction as moderate. Clozapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitory activity and may add to serotonergic effects of clozapine, with a theoretical risk of serotonin toxicity. Both drugs can also cause CNS depression, and clozapine carries a risk of neuroleptic malignant syndrome. Procarbazine is also myelosuppressive, adding to clozapine's risk of neutropenia.
How serious is the interaction between Clozapine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, rigidity and autonomic instability, and follow blood counts closely. Consider an alternative antipsychotic if marrow suppression develops.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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