Drug interactions
clozapine + ritonavir
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ clozapine levels/toxicity.
Mechanism of action
CYP inhibition.
Clinical management
Avoid or monitor levels closely.
Drug reference
References
Frequently asked questions
Can I take clozapine with ritonavir?
The interaction is rated: Major. ↑ clozapine levels/toxicity.
How serious is the interaction between clozapine and ritonavir?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between clozapine and ritonavir managed?
Avoid or monitor levels closely.
Why do clozapine and ritonavir interact?
CYP inhibition.
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