Drug interactions
Clozapine + Sertraline
Severity: Moderate
Clozapine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline may raise clozapine concentrations through CYP2D6 and other enzyme inhibition, increasing the risk of sedation, seizures and orthostasis. Both drugs may also affect the QT interval.
What this interaction means in plain words
Clozapine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Inhibition of CYP-mediated clozapine metabolism by sertraline with additive QT effects.
What to do
Monitor clozapine levels and adverse effects when sertraline is started, changed or stopped, and adjust the clozapine dose as needed. Check ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Sertraline?
MediHelp rates the interaction as moderate. Clozapine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline may raise clozapine concentrations through CYP2D6 and other enzyme inhibition, increasing the risk of sedation, seizures and orthostasis. Both drugs may also affect the QT interval.
How serious is the interaction between Clozapine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clozapine levels and adverse effects when sertraline is started, changed or stopped, and adjust the clozapine dose as needed. Check ECG in patients with cardiac risk factors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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