Drug interactions
Clozapine + Tamsulosin
Severity: Moderate
Clozapine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has marked alpha-1 blocking activity, so combining it with tamsulosin may produce additive orthostatic hypotension and syncope. Any pharmacokinetic effect via CYP2D6 is minor.
What this interaction means in plain words
Clozapine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade, with possible minor CYP2D6 inhibition.
What to do
Monitor blood pressure and orthostatic symptoms, especially during clozapine titration. Lower the tamsulosin dose if dizziness or syncope occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Tamsulosin?
MediHelp rates the interaction as moderate. Clozapine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has marked alpha-1 blocking activity, so combining it with tamsulosin may produce additive orthostatic hypotension and syncope. Any pharmacokinetic effect via CYP2D6 is minor.
How serious is the interaction between Clozapine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially during clozapine titration. Lower the tamsulosin dose if dizziness or syncope occurs.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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