Drug interactions
Clozapine + Tiotropium
Severity: Moderate
Clozapine and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly anticholinergic, and combining it with tiotropium raises the risk of constipation, which can progress to serious gastrointestinal hypomotility, as well as urinary retention and tachycardia. Systemic exposure to tiotropium is low, but the additive effect is still relevant.
What this interaction means in plain words
Clozapine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor bowel function and ask about constipation regularly; start laxatives early if needed. Watch for urinary retention and tachycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Tiotropium?
MediHelp rates the interaction as moderate. Clozapine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly anticholinergic, and combining it with tiotropium raises the risk of constipation, which can progress to serious gastrointestinal hypomotility, as well as urinary retention and tachycardia. Systemic exposure to tiotropium is low, but the additive effect is still relevant.
How serious is the interaction between Clozapine and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and ask about constipation regularly; start laxatives early if needed. Watch for urinary retention and tachycardia.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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