Drug interactions
Clozapine + Umeclidinium-vilanterol
Severity: Moderate
Clozapine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can prolong the QT interval and cause tachycardia and has strong anticholinergic activity. With vilanterol and umeclidinium, cardiac stimulation and anticholinergic effects such as constipation or urinary retention may be additive.
What this interaction means in plain words
Clozapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation, tachycardia and anticholinergic effects.
What to do
Monitor heart rate, ECG in at-risk patients and electrolytes. Monitor for constipation and urinary retention, as clozapine-induced hypomotility can be serious.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Clozapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can prolong the QT interval and cause tachycardia and has strong anticholinergic activity. With vilanterol and umeclidinium, cardiac stimulation and anticholinergic effects such as constipation or urinary retention may be additive.
How serious is the interaction between Clozapine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG in at-risk patients and electrolytes. Monitor for constipation and urinary retention, as clozapine-induced hypomotility can be serious.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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