Drug interactions
Clozapine + Voclosporin
Severity: Moderate
Clozapine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin may prolong the QT interval, and clozapine has similar effects, so the combination could increase the risk of arrhythmia. Voclosporin also commonly causes electrolyte disturbances such as hyperkalemia, which may compound the risk.
What this interaction means in plain words
Clozapine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline and follow-up ECG and monitor potassium and magnesium during combined treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Clozapine with Voclosporin?
MediHelp rates the interaction as moderate. Clozapine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin may prolong the QT interval, and clozapine has similar effects, so the combination could increase the risk of arrhythmia. Voclosporin also commonly causes electrolyte disturbances such as hyperkalemia, which may compound the risk.
How serious is the interaction between Clozapine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG and monitor potassium and magnesium during combined treatment.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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