Drug interactions
Cobicistat + Diazepam
Severity: Moderate
Cobicistat and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and can raise diazepam concentrations, prolonging sedation and increasing the risk of respiratory depression, especially in older or frail patients.
What this interaction means in plain words
Cobicistat and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Diazepam belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated diazepam metabolism by cobicistat.
What to do
Start with a reduced diazepam dose and titrate carefully while monitoring sedation and respiratory status. Consider lorazepam or temazepam as alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Diazepam?
MediHelp rates the interaction as moderate. Cobicistat and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and can raise diazepam concentrations, prolonging sedation and increasing the risk of respiratory depression, especially in older or frail patients.
How serious is the interaction between Cobicistat and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a reduced diazepam dose and titrate carefully while monitoring sedation and respiratory status. Consider lorazepam or temazepam as alternatives.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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