Drug interactions
Cobicistat + Fluvastatin
Severity: Minor
Cobicistat and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin is metabolized mainly by CYP2C9, so cobicistat is expected to have only a limited effect on its levels. Some increase in exposure through transporter inhibition is possible.
What this interaction means in plain words
Cobicistat and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Fluvastatin belongs to Cardiovascular.
Why it happens
Possible weak inhibition of statin transporters by cobicistat; fluvastatin is primarily CYP2C9-metabolized.
What to do
Start with the lowest fluvastatin dose and titrate based on response and tolerance. Counsel the patient to report muscle pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Fluvastatin?
MediHelp rates the interaction as minor. Cobicistat and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvastatin is metabolized mainly by CYP2C9, so cobicistat is expected to have only a limited effect on its levels. Some increase in exposure through transporter inhibition is possible.
How serious is the interaction between Cobicistat and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest fluvastatin dose and titrate based on response and tolerance. Counsel the patient to report muscle pain.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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