Drug interactions
Cobicistat + Levonorgestrel
Severity: Minor
Cobicistat and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and may raise systemic levonorgestrel concentrations. With an intrauterine system, systemic exposure is low and the effect is probably small.
What this interaction means in plain words
Cobicistat and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Levonorgestrel belongs to Endocrine.
Why it happens
Cobicistat inhibits CYP3A4, reducing levonorgestrel metabolism.
What to do
No routine change is needed with an intrauterine system. Monitor for hormonal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Levonorgestrel?
MediHelp rates the interaction as minor. Cobicistat and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat inhibits CYP3A4 and may raise systemic levonorgestrel concentrations. With an intrauterine system, systemic exposure is low and the effect is probably small.
How serious is the interaction between Cobicistat and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed with an intrauterine system. Monitor for hormonal adverse effects.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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