Drug interactions
Cobicistat + Metformin-repaglinide
Severity: Moderate
Cobicistat and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and may increase repaglinide exposure, raising the risk of hypoglycemia. The effect may be pronounced when combined with other inhibitors.
What this interaction means in plain words
Cobicistat and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Cobicistat inhibits CYP3A4, reducing repaglinide metabolism.
What to do
Monitor blood glucose closely and consider reducing the repaglinide dose when starting cobicistat; counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Cobicistat and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and may increase repaglinide exposure, raising the risk of hypoglycemia. The effect may be pronounced when combined with other inhibitors.
How serious is the interaction between Cobicistat and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the repaglinide dose when starting cobicistat; counsel on hypoglycemia symptoms.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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