Drug interactions
Cobicistat + Netupitant-palonosetron
Severity: Minor
Cobicistat and Netupitant-palonosetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat strongly inhibits CYP3A4 and may increase netupitant concentrations. The labeling for netupitant/palonosetron does not require adjustment with CYP3A4 inhibitors, and the clinical effect is generally modest.
What this interaction means in plain words
Cobicistat and Netupitant-palonosetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Cobicistat inhibits CYP3A4, reducing the metabolism of netupitant.
What to do
No dose adjustment is needed. Be aware of possible increased netupitant-related adverse effects such as headache and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Netupitant-palonosetron?
MediHelp rates the interaction as minor. Cobicistat and Netupitant-palonosetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat strongly inhibits CYP3A4 and may increase netupitant concentrations. The labeling for netupitant/palonosetron does not require adjustment with CYP3A4 inhibitors, and the clinical effect is generally modest.
How serious is the interaction between Cobicistat and Netupitant-palonosetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of possible increased netupitant-related adverse effects such as headache and constipation.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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