Drug interactions
Cobicistat + Triamcinolone
Severity: Major
Cobicistat and Triamcinolone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a potent CYP3A4 inhibitor and can substantially increase systemic triamcinolone exposure. Cushing syndrome and adrenal suppression have been reported with similar combinations after injected triamcinolone.
What this interaction means in plain words
Cobicistat and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobicistat belongs to Miscellaneous; Triamcinolone belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4 reduces triamcinolone clearance.
What to do
Avoid combining where possible, especially for repeated or long-term use; use an alternative corticosteroid such as prednisolone or beclomethasone. If unavoidable, monitor for Cushingoid effects and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Triamcinolone?
MediHelp rates the interaction as major. Cobicistat and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a potent CYP3A4 inhibitor and can substantially increase systemic triamcinolone exposure. Cushing syndrome and adrenal suppression have been reported with similar combinations after injected triamcinolone.
How serious is the interaction between Cobicistat and Triamcinolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially for repeated or long-term use; use an alternative corticosteroid such as prednisolone or beclomethasone. If unavoidable, monitor for Cushingoid effects and adrenal suppression.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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