Drug interactions
Cobimetinib + Doxycycline
Severity: Minor
Cobimetinib and Doxycycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxycycline is not a clinically meaningful CYP3A4 inhibitor, so a significant increase in cobimetinib exposure is unlikely. Any effect would be small compared with true moderate inhibitors.
What this interaction means in plain words
Cobimetinib and Doxycycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobimetinib belongs to Oncology; Doxycycline belongs to Anti Bacterial.
Why it happens
Possible weak CYP3A4 inhibition, not firmly established for doxycycline.
What to do
No dose adjustment is usually required; monitor for cobimetinib toxicity such as rash, diarrhea, hemorrhage and CPK elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Doxycycline?
MediHelp rates the interaction as minor. Cobimetinib and Doxycycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxycycline is not a clinically meaningful CYP3A4 inhibitor, so a significant increase in cobimetinib exposure is unlikely. Any effect would be small compared with true moderate inhibitors.
How serious is the interaction between Cobimetinib and Doxycycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for cobimetinib toxicity such as rash, diarrhea, hemorrhage and CPK elevation.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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