Drug interactions
Cobimetinib + Nicardipine
Severity: Moderate
Cobimetinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobimetinib is a CYP3A4 substrate, and strong inhibitors greatly raise its exposure. Nicardipine is only a weak to moderate CYP3A4 inhibitor, so the effect is expected to be smaller than with strong inhibitors, but it may still increase cobimetinib toxicity such as rash, diarrhea, hemorrhage and liver enzyme elevations.
What this interaction means in plain words
Cobimetinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobimetinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine inhibition of CYP3A4-mediated metabolism of cobimetinib.
What to do
Monitor for cobimetinib adverse effects and liver enzymes, and consider a cobimetinib dose reduction if toxicity occurs. Prefer an antihypertensive without CYP3A4 inhibition if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Nicardipine?
MediHelp rates the interaction as moderate. Cobimetinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobimetinib is a CYP3A4 substrate, and strong inhibitors greatly raise its exposure. Nicardipine is only a weak to moderate CYP3A4 inhibitor, so the effect is expected to be smaller than with strong inhibitors, but it may still increase cobimetinib toxicity such as rash, diarrhea, hemorrhage and liver enzyme elevations.
How serious is the interaction between Cobimetinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cobimetinib adverse effects and liver enzymes, and consider a cobimetinib dose reduction if toxicity occurs. Prefer an antihypertensive without CYP3A4 inhibition if feasible.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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