Drug interactions
Cobimetinib + Quinidine
Severity: Moderate
Cobimetinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits CYP3A4 and P-glycoprotein and may raise cobimetinib exposure, increasing adverse effects such as hemorrhage, rhabdomyolysis, hepatotoxicity and retinopathy. Quinidine is only a weak-to-moderate CYP3A4 inhibitor, so the effect is smaller than with strong inhibitors.
What this interaction means in plain words
Cobimetinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobimetinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by quinidine reducing cobimetinib clearance.
What to do
Monitor for cobimetinib toxicity and consider a dose reduction if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Quinidine?
MediHelp rates the interaction as moderate. Cobimetinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits CYP3A4 and P-glycoprotein and may raise cobimetinib exposure, increasing adverse effects such as hemorrhage, rhabdomyolysis, hepatotoxicity and retinopathy. Quinidine is only a weak-to-moderate CYP3A4 inhibitor, so the effect is smaller than with strong inhibitors.
How serious is the interaction between Cobimetinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cobimetinib toxicity and consider a dose reduction if adverse effects occur.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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