Drug interactions
Cobimetinib + Sertraline
Severity: Minor
Cobimetinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobimetinib is a CYP3A4 substrate, and sertraline is only a weak CYP3A4 inhibitor, so the increase in exposure is likely small. A larger increase would raise risks such as bleeding, rash, diarrhea and photosensitivity.
What this interaction means in plain words
Cobimetinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobimetinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may modestly reduce cobimetinib clearance.
What to do
No dose change is generally needed. Monitor for adverse effects such as bleeding, rash and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Sertraline?
MediHelp rates the interaction as minor. Cobimetinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobimetinib is a CYP3A4 substrate, and sertraline is only a weak CYP3A4 inhibitor, so the increase in exposure is likely small. A larger increase would raise risks such as bleeding, rash, diarrhea and photosensitivity.
How serious is the interaction between Cobimetinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for adverse effects such as bleeding, rash and diarrhea.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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