Drug interactions
Cobimetinib + Ticagrelor
Severity: Moderate
Cobimetinib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A inhibitor and may modestly raise cobimetinib exposure, which could increase toxicities such as bleeding, rash and liver effects. Both drugs also carry bleeding risk, adding to the concern.
What this interaction means in plain words
Cobimetinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobimetinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Ticagrelor weakly inhibits CYP3A4, and both agents add to bleeding risk.
What to do
Monitor for cobimetinib adverse effects and bleeding. Consider whether an alternative antiplatelet is appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Ticagrelor?
MediHelp rates the interaction as moderate. Cobimetinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor is a weak CYP3A inhibitor and may modestly raise cobimetinib exposure, which could increase toxicities such as bleeding, rash and liver effects. Both drugs also carry bleeding risk, adding to the concern.
How serious is the interaction between Cobimetinib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cobimetinib adverse effects and bleeding. Consider whether an alternative antiplatelet is appropriate.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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