Drug interactions
Cocaine + Linezolid
Severity: Major
Cocaine and Linezolid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks reuptake of monoamines, including serotonin and norepinephrine, while linezolid inhibits MAO. Combined use may cause serotonin syndrome or hypertensive and sympathomimetic reactions.
What this interaction means in plain words
Cocaine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Monoamine reuptake inhibition by cocaine plus reduced monoamine metabolism through MAO inhibition by linezolid.
What to do
Avoid the combination where possible, especially with systemic or illicit cocaine. If exposure to cocaine occurs during linezolid therapy, monitor blood pressure, heart rate, temperature and mental status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Linezolid?
MediHelp rates the interaction as major. Cocaine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of monoamines, including serotonin and norepinephrine, while linezolid inhibits MAO. Combined use may cause serotonin syndrome or hypertensive and sympathomimetic reactions.
How serious is the interaction between Cocaine and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially with systemic or illicit cocaine. If exposure to cocaine occurs during linezolid therapy, monitor blood pressure, heart rate, temperature and mental status.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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