Drug interactions
Cocaine + Nadolol
Severity: Moderate
Cocaine and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
With nonselective beta-blockers, cocaine's alpha-adrenergic effects are unopposed, which may cause hypertension and coronary vasoconstriction. Topical cocaine has limited systemic absorption but this effect is still described for nonselective agents.
What this interaction means in plain words
Cocaine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
Why it happens
Beta-blockade leaves cocaine-induced alpha-mediated vasoconstriction unopposed.
What to do
Avoid cocaine use with nonselective beta-blockers where possible. If topical cocaine is required, monitor blood pressure and for chest pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Nadolol?
MediHelp rates the interaction as moderate. Cocaine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. With nonselective beta-blockers, cocaine's alpha-adrenergic effects are unopposed, which may cause hypertension and coronary vasoconstriction. Topical cocaine has limited systemic absorption but this effect is still described for nonselective agents.
How serious is the interaction between Cocaine and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine use with nonselective beta-blockers where possible. If topical cocaine is required, monitor blood pressure and for chest pain.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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