Drug interactions
Cocaine + Naratriptan
Severity: Moderate
Cocaine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, and may add to triptan serotonergic effects. Both also have vasoconstrictive potential. Topical clinical use delivers low systemic exposure, but misuse leads to much greater risk.
What this interaction means in plain words
Cocaine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and vasoconstriction from cocaine monoamine reuptake inhibition combined with triptan vasoconstrictive agonism.
What to do
Avoid triptans in patients using cocaine recreationally. With topical medical use, monitor for serotonin syndrome and elevated blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Naratriptan?
MediHelp rates the interaction as moderate. Cocaine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, and may add to triptan serotonergic effects. Both also have vasoconstrictive potential. Topical clinical use delivers low systemic exposure, but misuse leads to much greater risk.
How serious is the interaction between Cocaine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid triptans in patients using cocaine recreationally. With topical medical use, monitor for serotonin syndrome and elevated blood pressure.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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