Drug interactions
Cocaine + Nebivolol
Severity: Moderate
Cocaine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockade can leave cocaine-induced alpha-adrenergic vasoconstriction unopposed, potentially worsening hypertension and coronary vasospasm. With topical cocaine absorption is limited, but systemic effects remain possible.
What this interaction means in plain words
Cocaine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Blockade of beta-mediated vasodilation leaves alpha-adrenergic vasoconstriction unopposed.
What to do
Avoid or minimize cocaine use in patients on nebivolol; monitor blood pressure and for chest pain if topical cocaine is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Nebivolol?
MediHelp rates the interaction as moderate. Cocaine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockade can leave cocaine-induced alpha-adrenergic vasoconstriction unopposed, potentially worsening hypertension and coronary vasospasm. With topical cocaine absorption is limited, but systemic effects remain possible.
How serious is the interaction between Cocaine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or minimize cocaine use in patients on nebivolol; monitor blood pressure and for chest pain if topical cocaine is required.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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